|
|||
|
Prof. Dr. med. Vera Mahler
|
|
Research Interests:
clinical and molecular allergy/immunology
Type I allergy
recombinant allergens
cross-reactivity, plant allergens, latex-allergens
specific immunotherapy (SIT)
mouse models
atopic dermatitis
occupational dermatology
environmental medicine
prevention
Special clinical interests:
improvement of diagnostic means and therapy of type
I allergy by introduction of recombinant allergens
new adjuvans and elucidation of mechanisms of SIT and cross-allergy
Selected References:
Apfelbacher C.; Molin S.; Weisshaar E.; et al. Characteristics and care of patients with chronic hand eczema: update from the carpe registry. EXPERIMENTAL DERMATOLOGY 2012,21,3,e24-e24
Schnuch Axel; Mahler Vera; Elsner Peter; et al. The end of epicutaneous testing in allergy diagnostics? ALLERGOLOGIE 2012,35,3,152-153
Wangorsch A.; Weigand D.; Peters S.; et al. Identification of a Dau c PRPlike protein (Dau c 1.03) as a new allergenic isoform in carrots (cultivar Rodelika). CLINICAL AND EXPERIMENTAL ALLERGY 2012,42,1,156-166
Apfelbacher Christian Joachim; Akst Wilhelm; Molin Sonja; et al. CARPE: a registry project of the German Dermatological Society (DDG) for the characterization and care of chronic hand eczema. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 2011,9,9,682-688
Worm M.; Scherer K.; Koehli-Wiesner A.; et al. Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry. ALLERGOLOGIE 2011,34,7,329-337
Maurer Marcus; Altrichter Sabine; Bieber Thomas; et al. Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2011,28,1,202-U326
Peters Susanna; Imani Jafargholi; Mahler Vera; et al. Dau c 1.01 and Dau c 1.02-silenced transgenic carrot plants show reduced allergenicity to patients with carrot allergy. TRANSGENIC RESEARCH 2011,20,3,547-556
Geier J.; Mahler V; John S. M. Consequences of the 15th Amendment of the Medicines Act - Current Status. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 2011,9,Suppl.1,7-7
Mahler V. Protein contact dermatitis - A diagnostic Challenge. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 2011,9,Suppl. 1,101-101
Mahler V. Occupational dermatology issues and Patient care in Hospitals and Ambulances. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 2011,9,Suppl. 1,127-127
Hillen U, Dickel H, Löffler H, Pfützner W, Mahler V, Becker D, Brasch J, Worm M, Fuchs T, John SM, Geier J. Late reactions to patch test preparations with reduced concentrations of p-phenylenediamine: a multicentre investigation of the German Contact Dermatitis Research Group. Contact Dermatitis. 2011 Apr;64(4):196-202.
Ott H, Schröder C, Raulf-Heimsoth M, Mahler V, Ocklenburg C, Merk HF, Baron JM
Microarrays of recombinant Hevea brasiliensis proteins: a novel tool for the component-resolved diagnosis of natural rubber latex allergy.
J Investig Allergol Clin Immunol. 2010;20(2): 129-38
Mahler Vera; Boysen Morten; Brondbo Kjell. Radiotherapy or CO(2) laser surgery as treatment of T(1a) glottic carcinoma? EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 2010,267,5,743-750
Feser A, Mahler V
Periorbital dermatitis: causes, differential diagnoses and therapy.
J Dtsch Dermatol Ges. 2010;8(3): 159-66
Heratizadeh A, Killig C, Worm M, Soost S, Simon D, Bauer A, Mahler V, Schuster C, Szliska C, Frambach Y, Eben R, Werfel T, Uter W, Schnuch A.
Quantitative repeated open application testing with a rinse-off product in methyldibromo glutaronitrile-sensitive patients: results of the IVDK.
Contact Dermatitis. 2010;62(6): 330-7
Le LQ, Mahler V, Scheurer S, Foetisch K, Braun Y, Weigand D, Enrique E, Lidholm J, Paulus KE, Sonnewald S, Vieths S, Sonnewald U.
Yeast profilin complements profilin deficiency in transgenic tomato fruits and allows development of hypoallergenic tomato fruits.
FASEB J. 2010;24(12): 4939-47
Mahler V, Erfurt-Berge C, Schiemann S, Michael S, Egloffstein A, Kuss O
Dirt-binding particles consisting of hydrogenated castor oil beads constitute a nonirritating alternative for abrasive cleaning of recalcitrant oily skin contamination in a three-step programme of occupational skin protection.
Br J Dermatol. 2010;162(4): 812-8
Erfurt-Berge C.; Schuler-Thurner B.; Mahler V.; et al. Unexpected induction of delayed type hypersensitivity (DTH) to human serum albumin in melanoma patients by Dendritic Cell vaccination. EXPERIMENTAL DERMATOLOGY 2010,19,2,207-207
Oschem M, Mahler V, Prokosch HU.
Objectifying User Critique.
Methods Inf Med. 2010 Jan 20;49(2). [Epub ahead of print]
Schnuch A, Uter W, Dickel H, Szliska C, Schliemann S, Eben R, Ruëff F, Gimenez-Arnau A, Löffler H, Aberer W, Frambach Y, Worm M, Niebuhr M, Hillen U, Martin V, Jappe U, Frosch PJ, Mahler V.
Quantitative patch and repeated open application testing in hydroxyisohexyl 3-cyclohexene carboxaldehyde sensitive-patients.
Contact Dermatitis. 2009 Sep;61(3):152-62
Colsman A, Kunzmann U, Seggewies C, Mahler V.
[Preparing dermatological discharge reports within an electronic clinical information systems. A pilot investigation regarding medical and economical aspects]
Hautarzt. 2009 Oct;60(10):821-5. German.
Geier, J, Lessmann, H, Hellweg, B, Jappe, U, Spornraft-Ragaller, P, Fuchs, T, Aberer, W, Frosch, PJ, Weisshaar, E, Mahler, V, Loffler, H, Skudlik, C, Szliska, C, Koch, P, Pfohler, C, Lilie, M, Becker, D, Trcka, J, Meyer, J, Hahn, JU, Adam, M. Chromated metal products may be hazardous to patients with chromate allergy. CONTACT DERMATITIS 2009, 60 (4): 199-202
Uter, W, Ramsch, C, Aberer, W, Ayala, F, Balato, A, Beliauskiene, A, Fortina, AB, Bircher, A, Brasch, J, Chowdhury, MMU, Coenraads, PJ, Schuttelaar, ML, Cooper, S, Corradin, MT, Elsner, P, English, JSC, Fartasch, M, Mahler, V, Frosch, PJ, Fuchs, T, Gawkrodger, DJ, Gimenez-Arnau, AM, Green, CM, Horne, HL, Jolanki, R, King, CM, Krecisz, B, Kiec-Swierczynska, M, Ormerod, AD, Orton, DI, Peserico, A, Rantanen, T, Rustemeyer, T, Sansom, JE, Simon, D, Statham, BN, Wilkinson, M, Schnuch, A. The European baseline series in 10 European Countries, 2005/2006-Results of the European Surveillance System on Contact Allergies (ESSCA). CONTACT DERMATITIS 2009, 61 (1): 31-38
Busch, M., Schroder, C., Baron, J. M., Ott, H., Bruckner, T., Diepgen, T. L., and Mahler, V. (2008). Glove-derived foreign proteins induce allergen-specific IgE in a mouse model. Journal of Investigative Dermatology 128, 890-896.
Busch, M., Schroder, C., Baron, J. M., Ott, H., Bruckner, T., Diepgen, T. L., and Mahler, V. (2008). Recombinant allergen-based micro array: detection of specific IgE to unexpected glove-derived allergens in a mouse model. Experimental Dermatology 17 , 242.
Feser, A., Plaza, T., Vogelgsang, L., and Mahler, V. (2008). Periorbital dermatitis-a recalcitrant disease: causes and differential diagnoses. British Journal of Dermatology 159, 858-863.
Jacobi, A., Braeutigam, M., Mahler, V., Schultz, E., and Hertl, M. (2008). Pimecrolimus 1% cream in the treatment of facial psoriasis: A 16-week open-label study. Dermatology 216, 133-136.
Mahler, V. (2008). Recombinant allergens for diagnosis and for specific immunotherapy. Allergologie 31, 434.
Pfoch, L., Mahler, V., Sticherling, M.
Drug-Eluting Coronary Stents: Hypersensitivity Reactions to Paclitaxel
Dermatology (DOI:10.1159/000171817)
Published Online: November 6, 2008
Schnuch, A., Aberer, W., Agathos, M., Becker, D., Brasch, J., Elsner, P., Frosch, P. J., Fuchs, T., Geier, J., Hillen, U., Loffler, H., Mahler, V., Richter, G., and Szliska, C. (2008). Performing patch testing with contact allergens. Journal der Deutschen Dermatologischen Gesellschaft 6, 770-775.
Thumann, P., Topf, S., Feser, A., Erfurt, C., Schuler, G., and Mahler, V. (2008). Digital speech recognition in dermatology. A pilot study with regard to medical and economic aspects. Hautarzt 59, 131-134.
Worm M, Aberer W, Agathos M, Becker D, Brasch J, Fuchs T, Hillen U, Hoger P, Mahler V, Schnuch A, Szliska C; German Contact Dermatitis Research Group (DKG).
Patch testing in children--recommendations of the German Contact Dermatitis Research Group (DKG).
J Dtsch Dermatol Ges. 2007 Feb;5(2):107-9. English, German. Erratum in: J Dtsch Dermatol Ges. 2007 Jun;5(6):541.
Mahler V.
Skin protection in the healthcare setting.
Curr Probl Dermatol. 2007;34:120-32.
Thoma-Uszynski S, Mahler V.
Incomplete auriculotemporal nerve syndrome--mimicry of oral allergy syndrome.
Eur J Dermatol. 2007 Mar-Apr;17(2):157-9. Epub 2007 Mar 2.
Schuh A, Thomas P, Reinhold R, Holzwarth U, Zeiler G, Mahler V.
[Allergic reaction to components of bone cement after total knee arthroplasty]
Zentralbl Chir. 2006 Oct;131(5):429-31. German.
Le LQ, Mahler V, Lorenz Y, Scheurer S, Biemelt S, Vieths S, Sonnewald U.
Reduced allergenicity of tomato fruits harvested from Lyc e 1-silenced transgenic tomato plants.
J Allergy Clin Immunol. 2006 Nov;118(5):1176-83. Epub 2006 Sep 8.
Mahler V, Gutgesell C, Valenta R, Fuchs T.
Natural rubber latex and hymenoptera venoms share ImmunoglobinE-epitopes accounting for cross-reactive carbohydrate determinants.
Clin Exp Allergy. 2006 Nov;36(11):1446-56.
Jacobi A, Mahler V, Schuler G, Hertl M.
Treatment of inflammatory dermatoses by tumour necrosis factor antagonists.
J Eur Acad Dermatol Venereol. 2006 Nov;20(10):1171-87.
Brasch J, Weichenthal M, Szliska C, Loffler H, Koch P, Grabbe J, Mahler V, Kreilgard B, Hoeck U; German Contact Dermatitis Research Group.
Positive patch test reactions to nickel sulphate are not modified by neighbouring negative fragrance patch tests. A multicenter-study by the German contact dermatitis research group.
Acta Derm Venereol. 2006;86(4):345-7.
Diepgen TL, Bruynzeel DP, Andersen KE, Brandao FM, Bruze M, Goncalo M, Goossens A, Lahti A, Mahler V, Menne T, White IR, Wilkinson JD; European Environmental Contact Dermatitis Research Group (EECDRG).
Mercaptobenzothiazole or the mercapto-mix: which should be in the standard series?
Contact Dermatitis. 2006 Jul;55(1):36-8.
Coors EA, Seybold H, Merk HF, Mahler V.
Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions.
Annals of Allergy, Asthma and Immunology 95:593-599; 2005
Becker D, Mahler V, Szliska C, Loffler H, Brasch J, Hillen U, Schnuch A, Elsner P.
The concentration of para-phenylenediamine (PPD) for routine patch testing in a
standard series needs to be redefined.
Contact Dermatitis. 2005 Sep;53(3):186-7. No abstract available.
Bruynzeel DP, Diepgen TL, Andersen KE, Brandao FM, Bruze M, Frosch PJ, Goossens A, Lahti A, Mahler V, Maibach HI, Menne T, Wilkinson JD; European Environmental and Contact Dermatitis Research Group.
Monitoring the European standard series in 10 centres 1996-2000.
Contact Dermatitis. 2005 Sep;53(3):146-9.
Uter W, Hegewald J, Aberer W, Ayala F, Bircher AJ, Brasch J, Coenraads PJ, Schuttelaar ML, Elsner P, Fartasch M, Mahler V, Belloni Fortina A, Frosch PJ, Fuchs T, Johansen JD, Menne T, Jolanki R, Krecisz B, Kiec-Swierczynska M, Larese F, Orton D, Peserico A, Rantanen T, Schnuch A.
The European standard series in 9 European countries, 2002/2003 -- first results of the European Surveillance System on Contact Allergies.
Contact Dermatitis. 2005 Sep;53(3):136-45.
Schnuch A, Kelterer D, Bauer A, Schuster Ch, Aberer W, Mahler V, Katzer K,
Rakoski J, Jappe U, Krautheim A, Bircher A, Koch P, Worm M, Loffler H, Hillen U,
Frosch PJ, Uter W.
Quantitative patch and repeated open application testing in methyldibromo
glutaronitrile-sensitive patients.
Contact Dermatitis. 2005 Apr;52(4):197-206.
Mahler V.
[Evidence-based treatment of skin diseases caused by herpesvirus.]
Hautarzt. 2005 Mar;56(3):241-50. German.
Diepgen TL, Dickel H, Becker D, Geier J, Mahler V, Schmidt A, Schwanitz HJ,
Skudlik C, Wagner E, Wehrmann W, Weisshaar E, Werfel T, Blome O.
[Evidence-based evaluation of the occupational relevance of different delayed
type sensitizations or allergens Begutachtung berufsbedingter Hautkrankheiten.]
Hautarzt. 2005 Mar;56(3):207-23. German.
Plaza T, Mahler V.
[Anaphylactic shock due to French galette. Type I allergic reaction to
buckwheat]
Hautarzt. 2005 Feb;56(2):160-3. German.
Mahler V, Drexler H.
Berufsdermatologisch relevante Typ-I-Allergien
Hautarzt. 2004 Jan;55(1):34-41. German.
Mahler V, Vrtala S, Kuss O, Diepgen T, Suck R, Cromwell O, Fiebig H, Hartl A, Thalhamer J, Schuler G, Kraft D, Valenta R.
Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1.
Clin Exp Allergy. 2004 Jan; 34(1): 115-122.
Budde IK, de Heer PG, Natter S, Mahler V, van der Zee JS, Valenta R, Aalberse RC.
Studies on the association between immunoglobulin E autoreactivity and immunoglobulin E-dependent histamine-releasing factors.
Immunology. 2002 Oct;107(2):243-51.
Schultz E, Mahler V.
Prolonged lichenoid reaction and cross-sensitivity to para-substituted amino-compounds due to temporary henna tattoo.
Int J Dermatol. 2002 May;41(5):301-3. No abstract available.
Diepgen TL, Mahler V.
The epidemiology of skin cancer.
Br J Dermatol. 2002 Apr;146 Suppl 61:1-6. Review.
Mahler, V., Fischer, S., Heiss, S., Duchêne, M., Kraft, D., Valenta, R. (2001).
cDNA cloning and characterization of a crossreactive birch pollen allergen: Identification as a pectinesterase.
Int Arch Allergy Immunol 124, 64-6
Focke, M., Mahler, V., Ball, T., Sperr, W.R., Valent, P., Kraft, D., Valenta, R. (2001).
Non-anaphylactic synthetic peptids derived from B-cell epitopes of the major grass pollen allergen Phl p 1, for allergy vaccination.
FASEB J 15, 2042-4
Binder M, Mahler V, Hayek B, Sperr WR, Schöller M, Prozell S, Wiedermann G, Valent P, Valenta R, Duchêne M. (2001).
Cloning of a major cross-reactive invertebrate allergen from Indianmeal moth Plodia interpunctella: Identification as an arginine kinase.
J Immunol 167, 5470-7
Mahler, V., Diepgen, T.L., Kuß, O., Leakakos, T., Truscott, W., Schuler, G., Kraft, D., Valenta, R. (2000).
Mutual boosting effects of sensitization with timothy grass pollen and latex glove extract on IgE antibody responses in a mouse model.
J Invest Dermatol 11, 1039-43
Mahler, V., Fischer, S., Fuchs, T., Ghannadan, M., Valent, P., Fartasch, M., Kraft, D., Schuler, G., Valenta, R. (2000).
Prevention of latex allergy by selection of low allergen gloves.
Clin Exp Allergy 30, 509-20
Grote, M., Mahler, V., Spitzauer, S., Fuchs, T., Valenta, R., Reichelt, R. (2000).
In situ localisation of latex allergens in three different brands of latex gloves by immunogold field emission scanning and transmission electron microscopy.
J Allergy Clin Immunol 105, 561-9
Heiss, S., Mahler, V., Steiner, R., Spitzauer, S., Schweiger, C., Kraft, D., Valenta, R. (1999).
Component-resolved diagnosis (CRD) of Type I allergy with recombinant grass and tree pollen allergens by skin testing.
J Invest Dermatol 113, 830-837
Mahler, V., Antoni, C., Anhalt, G.J., Koch, H.J., Peters, K.P., Manger, B., Kalden, J.R., Hornstein, O.P. (1998)
Graft versus host-like mucocutaneous eruptions and serologic features of paraneoplastic pemphigus and systemic lupus erythematosus in a patient with non-Hodkin's lymphoma.
Dermatology 197, 78-83
