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Priv.-Doz. Dr. med. Sybille Thoma-Uszynski
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Research Interests:
native and adaptive immune system
antigen presentation
immune pathogenesis of autoimmunity
bullous autoimmune diseases
bullous pemphigoid as a model of T cell
triggered autoantibodymediated autoimmune disease
autoantigens, particular BP180 and BP230
extracellular matrix molecules
immune modulation
Special clinical interests:
Role of T cells in the immune
pathogenesis of bullous pemphigoid
Identification of T cell epitopes
of the BP180 bullous pemphigoid autoantigen
Characterization of autoantibody
profile in bullous pemhigoid
Development of immunmodulatory strategies
in the treatment of bullous pemphigoid
Selected References:
Di Zenzo G, Thoma-Uszynski S, Calabresi V, Fontao L, Hofmann SC, Lacour JP, Sera F, Bruckner-Tuderman L, Zambruno G, Borradori L, Hertl M. Demonstration of Epitope-Spreading Phenomena in Bullous Pemphigoid: Results of a Prospective Multicenter Study. J Invest Dermatol. 2011,131,11,2271-2280
Huffmeier, U ; Lascorz, J ; Becker, T ; Schurmeier-Horst, F ; Magener, A ; Ekici, AB ; Endele, S ; Thiel, CT ; Thoma-Uszynski, S ; Mossner, R ; Reich, K ; Kurrat, W ; Wienker, TF ; Traupe, H ; Reis, A. Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1. JOURNAL OF MEDICAL GENETICS, 46 (11): 736-744 NOV 2009
Kazakov DV, Thoma-Uszynski S, Vanecek T, Kacerovska D, Grossmann P, Michal M.
A case of Brooke-Spiegler syndrome with a novel germline deep intronic mutation in the CYLD gene leading to intronic exonization, diverse somatic mutations, and unusual histology.
Am J Dermatopathol. 2009 Oct;31(7):664-73.
Rose, C, Schmidt, E, Kerstan, A, Thoma-Uszynski, S, Wesselmann, U, Kasbohrer, U, Zillikens, D, Shimanovich, I. Histopathology of anti-laminin 5 mucous membrane pemphigoid. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 61 (3): 433-440 SEP 2009.
Huffmeier, U, Lascorz, J, Becker, T, Schurmeyer-Horst, F, Magener, A, Ekici, AB, Endele, S, Thiel, CT, Thoma-Uszynski, S, Mossner, R, Reich, K, Kurrat, W, Wienker, TF, Traupe, H, Reis, A. Characterization of Psoriasis Susceptibility Locus 6 (PSORS6) in Patients with Early Onset Psoriasis and Evidence for Interaction with PSORS1. EXPERIMENTAL DERMATOLOGY, 18 (3): 285-285 MAR 2009
Di Zenzo, G., Thoma-Uszynski, S., Calabresi, V., Fontao, L., Hofmann, S. C., Lacour, I., Bruckner-Tuderman, L., Borradori, L., Zambruno, G., and Hertl, M. (2008). Evidence for intra- and inter-molecular epitope spreading involving the bullous pemphigoid 180 (BP180) and BP230 antigens in the immune pathogenesis of BP. Journal of Investigative Dermatology 128, 131.
Di Zenzo, G., Thoma-Uszynski, S., Fontao, L., Calabresi, V., Hofmann, S. C., Hellmark, T., Sebbag, N., Pedicelli, C., Sera, F., Lacour, J. P., Wieslander, J., Bruckner-Tuderman, L., Borradori, L., Zambruno, G., and Hertl, M. (2008). Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid. Clinical Immunology 128, 415-426.
Thoma-Uszynski, S. and Mahler, V. (2007). Incomplete auriculotemporal nerve syndrome - mimicry of oral allergy syndrome. European Journal of Dermatology 17, 157-159.
Di Zenzo, G., Thoma-Uszynski, S., Fontao, L., Calabresi, V., Hofmann, S. C., Lacour, J. P., Bruckner-Tuderman, L., Borradori, L., Zambruno, G., and Hertl, M. (2006). Multicenter prospective study of the humoral autoimmune response in a large cohort of bullous pemphigoid patients. Journal of Investigative Dermatology 126, 22.
Thoma-Uszynski S, Uter W, Schwietzke S, Schuler G, Borradori L, Hertl M.
Autoreactive T and B Cells from Bullous Pemphigoid (BP) Patients Recognize Epitopes Clustered in Distinct Regions of BP180 and BP230.
J Immunol. 2006 Feb 1;176(3):2015-23.
Bekou V, Thoma-Uszynski S, Wendler O, Uter W, Schwietzke S, Hunziker T,
Zouboulis CC, Schuler G, Sorokin L, Hertl M.
Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous
pemphigoid sera by ELISA.
J Invest Dermatol. 2005 Apr;124(4):732-40.
Thoma-Uszynski S, Uter W, Schwietzke S, Hofmann SC, Hunziker T, Bernard P, Treudler R, Zouboulis CC, Schuler G, Borradori L, Hertl M.
BP230- and BP180-specific auto-antibodies in bullous pemphigoid.
J Invest Dermatol. 2004 Jun;122(6):1413-22.
Hofmann S, Thoma-Uszynski S, Hunziker T, Bernard P, Koebnick C, Stauber A, Schuler G, Borradori L, Hertl M.
Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain.
J Invest Dermatol. 2002 Nov;119(5):1065-73.
Baykal C, Thoma-Uszynski S, Hertl M.
Pemphigus vulgaris localized to the nose and cheeks.
J Am. Acad. Dermatol 2002 Dec;47(6):875-80.
Maczek C, Thoma-Uszynski S, Schuler G, Hertl M.
Pemphigoid mit ungewöhnlicher serologischer Reaktivität bei Hemmkörper-Hämophilie.
Hautarzt 2002 Jun;53(6):412-5. German.
Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Sieling PA, Barnes PF, Röllinghoff M, Boelcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ , Bloom BR, Modlin RL.
Induction of a direct antimicrobial activity through mammalian Toll-like receptors.
Science 291: 1544-1547 (2001)
Ochoa MT, Stenger S, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL.
T-cell release of granulysin contributes to host defense in leprosy.
Nature Medicine 7: 174-179 (2001)
Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL.
Role of granulysin in immunity to leprosy.
Lepr Rev 71 Suppl: S115; discussion S115-6 (2000)
Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL.
Granulysin, a T cell product, kills bacteria by altering membrane permeability.
J Immunol 165: 7102-8 (2000).
Thoma-Uszynski S, Stenger S, Modlin RL.
CTL-Mediated killing of intracellular Mycobacterium tuberculosis is independent of target cell nuclear apoptosis.
J Immunol 165: 5773-9 (2000)
Cho S, Mehra V, Thoma-Uszynski S, Stenger S, Serbina N, Mazzaccaro RJ, Flynn JL, Barnes PF, Southwood S, Celis E, Bloom BR, Modlin RL, Sette A.
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.
Proc Natl Acad Sci U S A. 97: 12210-5 (2000)
Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL.
Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10.
J Immunol 165: 3804-10 (2000)
Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL.
An antimicrobial activity of cytolytic T cells mediated by granulysin.
Science 282: 121-5 (1998)
Thoma-Uszynski S, Emoto M, Kaufmann SH.
CD8aa T cells in lesions of Listeria monocytogenes-infected b2m-deficient mice.
Microb Pathog 23: 101-6 (1997)
Thoma-Uszynski S, Simnacher U, Marre R, Essig A.
Clearance of Chlamydia trachomatis-induced polyserositis in SCID mice requires both CD4+ and CD8+ cells.
Med Microbiol Immunol 187: 71-8 (1998)
Thoma-Uszynski S, Ladel CH, Kaufmann SH.
Abscess formation in Listeria monocytogenes-infected gd T cell deficient mouse mutants involves ab T cells.
Microb Pathog 22:123-8 (1997)
Books:
Thoma-Uszynski S, M. Hertl.
ANovel therapeutic approaches of autoimmune skin disorders. In Hertl M. (Hrsg.): Autoimmune diseases of the skin.
Springer Verlag, Wien/New York, 2001
