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Dr. med. Michael Erdmann
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Research Interests:
Immunotherapy (Dendritic cells in malignant melanoma)
Improvement in DC production (counterflow elutriation, maturation)
Monitoring of immune responses (mixted lymphocyte and peptide culture)
Special clinical interests:
Treatment of malignant melanoma
Ultrasound in dermatology
Selected References:
Erdmann M.; Simon M. Lupus vulgaris. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 2011,9,Suppl.1,205-205
Schuler-Thurner B.; Erdmann M.; Voland S.; et al. Vaccination with class I and II tumor peptide-loaded, cocktail-matured monocyte-derived DCs demonstrates solid immunogenicity and prolonged survival in a subset of melanoma patients exhibiting a particular gene expression profile. EXPERIMENTAL DERMATOLOGY 2011,20,2,188-188
Strasser E. F.; Erdmann M.; Weiss D. R.; et al. 10 YEARS EXPERIENCE OF MONOCYTE COLLECTION TO PRODUCE MONOCYTE DERIVED DENDRITIC CELLS FOR CANCER VACCINES (REVIEW). VOX SANGUINIS 2010,99,Suppl.1,267-267
Erfurt-Berge C.; Schuler-Thurner B.; Mahler V.; et al. Unexpected induction of delayed type hypersensitivity (DTH) to human serum albumin in melanoma patients by Dendritic Cell vaccination. EXPERIMENTAL DERMATOLOGY 2010,19,2,207-207
Schliep S.; Schliep K.; Erdmann M.; et al. Comparison of the serum tumor markers S100 and melanoma inhibitory activity (MIA) in the monitoring of melanoma patients undergoing dendritic cell vaccination. EXPERIMENTAL DERMATOLOGY 2010,19,2,221-221
Erdmann MK. Immunity unleashed in melanoma.
Lancet Oncol. 2010;11(2): 108-9
Erdmann, M, Kiesewetter, F, Schuler, G, Schultz, E. Erosive pustular dermatosis of the leg in a patient with ankylosing spondylitis: neutrophilic dysfunction as a common etiological factor? INTERNATIONAL JOURNAL OF DERMATOLOGY, 48 (5): 513-515 MAY 2009
Haendle, I., Schmitt-Haendle, M., Voland, S., Erdmann, M., Schliep, S., Schaft, N., Doerrie, J., Kaempgen, E., Schuler-Thurner, B., and Schuler, G. (2008). T-cell responses in stage IV melanoma patients vaccinated with dendritic cells electroporated with defined RNA. Experimental Dermatology 17, 263.
Lehner, M., Schmid, M., Diessenbacher, P., Leverkus, M., Erfurt, C., Erdmann, M., Kaempgen, E., and Holter, W. (2008). Dendritic cell survival during differentiation and maturation depends on anti-apoptotic effects of TNF. Experimental Dermatology 17, 263.
Erdmann, M., Haendle, I., Schmitt-Haendle, M., Leisgang, W., Trump, S., Wiesinger, M., Theiner, G., Kaempgen, E., Schuler-Thurner, B., and Schuler, G. (2008). Comparison of immune responses after vaccination with tumour-peptide-loaded dendritic cells with or without prior denileukin diftitox treatment in metastasized malignant melanoma. Experimental Dermatology 17, 267.
Erdmann, M., Haendle, I., Wiesinger, M., Leisgang, W., Trump, S., Coulie, P., Kampgen, E., Schuler-Thurner, B., and Schuler, G. (2007). Immune responses and clinical outcome of immunotherapy with peptide-loaded dendritic cells in 60 patients with metastasized malignant melanoma. Experimental Dermatology 16, 228.
Dorrie, J., Erdmann, M., Schaft, N., Muller, I., Stoica, D., Hirsch, U., Kampgen, E., Schuler-Thurner, B., and Schuler, G. (2007). Electroporation of ELUTRA generated dendritic cells with RNA - Towards a closed system. Experimental Dermatology 16, 230-231.
Schmid, M. A., Heise, D., Erfurt, C., Erdmann, M., Sorg, R., Schuler, G., Schuler-Thurner, B., and Kampgen, E. (2007). Tumor necrosis factor alpha is essential for monocyte survival and differentiation into immature dendritic cells. Experimental Dermatology 16, 231-232.
Erdmann M, Dörrie J, Schaft N, Strasser E, Hendelmeier M, Kämpgen E, Schuler G, Schuler-Thurner B. (2007). Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection. J Immunother. 30(6): 663-74
Erdmann, M., Haendle, I., Leisgang, W., Wiesinger, M., Coulie, P., Schuler-Thurner, B., and Schuler, G. (2006). Monitoring immune responses of vaccination with dendritic cells by ELISPOT and mixed lymphocyte/peptide culture (MLPC). Journal of Investigative Dermatology 126, S24.
